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KMID : 0613320120180010014
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Journal of the Korean Bone and Joint Tumor Soceity
2012 Volume.18 No. 1 p.14 ~ p.19
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Malignant Transformation of Benign Giant Cell Tumor
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Kong Chang-Bae
Hong Youn-Seok
Lee Kwang-Youl
Cho Sang-Hyun
Song Won-Seok
Cho Wan-Hyeong
Koh Jae-Soo
Jeon Dae-Geun
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Abstract
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Purpose: We analyzed the oncologic outcome of the malignant transformed benign giant cell tumor of bone.
Materials and Methods: Between January 2000 and February 2012, 5 cases were referred with suspicious malignant transformation of benign giant cell tumor. No patients underwent radiation therapy.
Results: After referral, all patients received the wide excision of the tumor and its’ pathologic diagnosis were osteosarcoma. As classifi ed by the location of tumor lesion, 3 cases were located in the distal femur, 1 case was in the distal radius and 1 case was in the proximal femur. The average latent period between diagnosis of benign giant cell tumor and diagnosis of secondary malignant giant cell tumor was 49.2 months. (range, 24-126 months) The mean follow-up period was 21.6 months. There were subsequent local recurrence in 2 cases and 3 patients developed distant metastasis. All patients with lung metastasis were dead.
Conclusion: Malignant transformation of benign giant cell tumor of bone can be occurred within 5 years. Therefore, when benign giant cell tumor suspicious malignant transformation, it is necessary to do more aggressive treatment.
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KEYWORD
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giant cell tumor, malignant transformation, osteosarcoma
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